Article Text
Abstract
Thiopurines are often the mainstay of treatment for many patients with inflammatory bowel disease. As such, a general understanding of the evidence behind their use and of their metabolism is extremely useful in clinical practice. This review gives a practical overview of thiopurine metabolism, the importance of thiopurine S-methyltransferase testing prior to the start of therapy and the monitoring of thioguanine nucleotide levels while on treatment, guiding a personalised approach to optimising thiopurine therapy.
- AZATHIOPRINE
- 6-MERCAPTOPURINE
- INFLAMMATORY BOWEL DISEASE
- THIOPURINE METHYLTRANSFERASE
- ADVERSE DRUG REACTIONS
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