Article Text

other Versions

PDF
Research
Bowel cancer screening is safe, detects earlier stage cancer and adenomas in 50% of cases: experience of the prevalent round of screening from two first wave centres in the North East of England
  1. P T Rajasekhar1,2,
  2. G M Clifford1,
  3. T J W Lee2,3,
  4. M D Rutter2,3,
  5. G Waddup3,
  6. M Ritchie1,
  7. D Nylander1,2,
  8. J Painter1,2,
  9. J Singh1,2,
  10. I Ward4,
  11. N Dempsey1,
  12. J Bowes1,
  13. G Handley4,
  14. J Henry1,
  15. C J Rees1,2
  1. 1South of Tyne Bowel Cancer Screening Centre, South Shields, UK
  2. 2The Northern Region Endoscopy Group, South Shields, UK
  3. 3Tees Bowel Cancer Screening Centre, Stockon-on-Tees, UK
  4. 4North of England Screening Hub, Gateshead, UK
  1. Correspondence to Dr C J Rees, South Tyneside NHS Foundation Trust, Harton Lane, South Shields NE34 0PL, UK; colin.rees{at}stft.nhs.uk

Abstract

Objective The NHS Bowel Cancer Screening Programme (BCSP) began roll-out in 2006 aiming to reduce cancer mortality through detection at an earlier stage. We report results from the prevalent round of screening at two first wave centres and compare with the UK pilot study.

Design This is a service evaluation study. Data were collected prospectively for all individuals undergoing faecal occult blood testing (FOBt) and colonoscopy including: uptake and outcomes of FOBt, colonoscopic performance, findings, histological data and complications. Continuous data were compared using a two-tailed test of two proportions.

Setting The South of Tyne and Tees Bowel Cancer Screening centres.

Patients Participants of the BCSP.

Main Outcome Measures 1) Colonoscopy Quality Assurance and 2) Cancer stage shift.

Results 195,772 individuals were invited to participate. Uptake was 54% and FOBt positivity 1.7%. 1524 underwent colonoscopy with caecal intubation in 1485 (97%). 180 (12%) cancers were detected. Dukes stages were: 76 (42%) A; 47 (26%) B; 47 (26%) C; 8 (4%) D and 2 (1%) unknown. This demonstrates a significantly earlier stage at diagnosis compared with data from 2867 non-screening detected cancers (p<0.001). Adenomas were detected in 758 (50%). One perforation occurred (0.07%) and two intermediate bleeds requiring transfusion only (0.12%). Both caecal intubation and adenoma detection were significantly higher than in the UK pilot study (p<0.001).

Conclusions The prevalent round of screening demonstrates a high adenoma and cancer detection rate and significantly earlier stage at diagnosis. Complications were few providing reassurance regarding safety. Efforts are required to improve uptake.

Statistics from Altmetric.com

Footnotes

  • Paper submitted in collaboration with the Northern Region Endoscopy Group.

  • Correction notice This article has been corrected since it was published Online First. The author name G Hanley has been amended to G Handley. This sentence has been amended: ‘non-screening detected cancers (p<0.001).’

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.