RT Journal Article SR Electronic T1 The use of optical imaging techniques in the gastrointestinal tract JF Frontline Gastroenterology JO Frontline Gastroenterol FD BMJ Publishing Group Ltd SP 207 OP 215 DO 10.1136/flgastro-2015-100563 VO 7 IS 3 A1 Sabina Beg A1 Ana Wilson A1 Krish Ragunath YR 2016 UL http://fg.bmj.com/content/7/3/207.abstract AB With significant advances in the management of gastrointestinal disease there has been a move from diagnosing advanced pathology, to detecting early lesions that are potentially amenable to curative endoscopic treatment. This has required an improvement in diagnostics, with a focus on identifying and characterising subtle mucosal changes. There is great interest in the use of optical technologies to predict histology and enable the formulation of a real-time in vivo diagnosis, a so-called ‘optical biopsy’. The aim of this review is to explore the evidence for the use of the current commercially available imaging techniques in the gastrointestinal tract.