PT - JOURNAL ARTICLE AU - Marinos Pericleous AU - Claire Kelly TI - The clinical management of hereditary haemochromatosis AID - 10.1136/flgastro-2017-100872 DP - 2017 Sep 23 TA - Frontline Gastroenterology PG - flgastro-2017-100872 4099 - http://fg.bmj.com/content/early/2017/09/23/flgastro-2017-100872.short 4100 - http://fg.bmj.com/content/early/2017/09/23/flgastro-2017-100872.full AB - Hereditary haemochromatosis is an autosomal recessive disorder with variable penetrance. Most patients are C282Y homozygotes while heterozygotes or patients who are homozygous with other mutations are uncommonly affected. The true genotype to phenotype expression remains unclear. Treatment with phlebotomy is highly effective and cost-efficient while liver transplantation confers a curative option.