TY - JOUR T1 - Long-term follow-up of the use of maintenance antibiotic therapy for chronic antibiotic-dependent pouchitis JF - Frontline Gastroenterology JO - Frontline Gastroenterol DO - 10.1136/flgastro-2017-100913 SP - flgastro-2017-100913 AU - Jonathan P Segal AU - Stephanie X Poo AU - Simon D McLaughlin AU - Omar D Faiz AU - Susan K Clark AU - Ailsa L Hart Y1 - 2018/01/31 UR - http://fg.bmj.com/content/early/2018/01/31/flgastro-2017-100913.abstract N2 - Objective Restorative proctolectomy is considered the procedure of choice in patients with ulcerative colitis who have failed medical therapy. Chronic pouchitis occurs in 10%–15% of patients, which often require long-term antibiotics to alleviate symptoms. Safety and efficacy of long-term maintenance antibiotics for chronic pouchitis has yet to be established. We aimed to assess the long-term safety and efficacy of maintenance antibiotic therapy for chronic pouchitis.Design This was an observational study. We followed up patients who were diagnosed with chronic antibiotic-dependent pouchitis.Setting Data were collected from our single specialist pouch centre.Patients Patients with chronic antibiotic-dependent pouchitis who had been maintained on antibiotics continuously for at least 1 year with a least one follow-up visit.Main outcome measure Development of pouch failure defined by the need for an ileostomy, patient-reported side effects of antibiotics and development of antibiotic resistance found on stool coliform testing.Results Long-term use of antibiotics achieve remission in 21% of patients over a median follow-up of 102 (range 9–125). Pouch failure in association with chronic pouchitis after a median follow-up of 8.5 years occurred in 18%. Side effects of long-term antibiotic use occurred in 28% of patients, with resistance to antibiotics from at least one stool sample occurring in 78% patients.Conclusions Although the use of antibiotics in chronic pouchitis may be justified, the use of long-term antibiotics must be weighed against potential complications associated with pouchitis and antibiotics. ER -