Biochemical/haematological | Histological |
---|---|
Hyperbilirubinaemia (>80 μmol/L) | Hepatocyte ballooning |
Raised AST (but less than 300 IU/mL) | Hepatocyte necrosis |
AST : ALT ratio >2 | Mallory-Denk bodies (cytoplasmic accumulations) |
Prolonged prothrombin time | Fibrosis; often pericellular |
Neutrophilia | Steatosis |
Giant mitochondria | |
Inflammatory infiltrate | |
Cholestasis | |
Bile duct proliferation? |
ALT, alanine transferase; AST, aspartate aminotransferase