Revised IAIHG diagnostic criteria (1999)
| Parameters/features | Score |
|---|---|
| Females | +2 |
| ALP:AST (or ALT) ratio | |
| <1.5 | +2 |
| 1.5–3.0 | 0 |
| >3.0 | −2 |
| Serum globulins or IgG above normal | |
| >2.0 | +3 |
| 1.5–2.0 | +2 |
| 1.0–1.5 | +1 |
| <1.0 | 0 |
| ANA, SMA or LKM1 titres | |
| >1/80 | +3 |
| 1:80 | +2 |
| 1:40 | +1 |
| <1:40 | 0 |
| AMA positive | −4 |
| Hepatitis markers | |
| Positive | −3 |
| Negative | +3 |
| Drug history | |
| Positive | −4 |
| Negative | +1 |
| Average alcohol consumption | |
| <25 g per day | +2 |
| >60 g per day | −2 |
| Liver histology | |
| Interface hepatitis | +3 |
| Predominantly lymphocytic infiltrate | +1 |
| Rosetting of liver cells | +1 |
| None of the above | −5 |
| Biliary changes | −3 |
| Other changes | −3 |
| Other autoimmune diseases | +2 |
| Optional additional parameters | |
| Seropositivity for other defined antibodies | +2 |
| HLA DR3 or DR4 | +1 |
| Response to therapy | |
| Complete | +2 |
| Relapse | +3 |
| Interpretation of aggregate scores | |
| Pretreatment | |
| Definite AIH | >15 |
| Probable AIH | 10–15 |
| Post-treatment | |
| Definite AIH | >17 |
| Probable AIH | 12–17 |
Adapted from Alvarez et al.22
AIH, autoimmune hepatitis; ANA, antinuclear antibody; HLA, human leucocyte antigen; IAIHG, International Autoimmune Hepatitis Group; LKM1, anti liver kidney microsome 1; SMA, antismooth muscle.