Drug concentration comparative studies
| Drug | Comparison | Pearson r correlation | Spearman r correlation | Agreement ICC (95% CI) | Mean difference, μg/mL (95% CI) | Reference |
|---|---|---|---|---|---|---|
| Infliximab | Sanquin ELISA–Leuven ELISA | 0.91 | – | 0.91 (0.86 to 0.95) | – | 35 |
| Sanquin ELISA–Theradiag ELISA | 0.83 | – | 0.73 (0.58 to 0.83) | – | ||
| Leuven ELISA–Theradiag ELISA | 0.73 | – | 0.59 (0.39 to 0.73) | – | ||
| Infliximab | Biomonitor RIA–Prometheus ELISA | 0.95 | 0.97 | 0.76 (0.29 to 0.90) | −3.12 (−3.98 to −2.25) | 36 |
| Biomonitor RIA–Prometheus HMSA | 0.96 | 0.97 | 0.82 (0.41 to 0.93) | −2.48 (−3.18 to −1.77) | ||
| Biomonitor RIA–RGA | 0.94 | 0.96 | 0.94 (0.90 to 0.96) | 0.32 (−0.09 to 0.74) | ||
| RGA–Prometheus ELISA | 0.91 | 0.95 | 0.72 (0.23 to 0.88) | −3.44 (−4.39 to −2.49) | ||
| RGA–Prometheus HMSA | 0.95 | 0.95 | 0.80 (0.30 to 0.92) | −2.80 (−3.54 to −2.06) | ||
| Prometheus ELISA–Prometheus HMSA | 0.97 | 0.97 | 0.96 (0.94 to 0.98) | 0.64 (0.15 to 1.12) | ||
| Infliximab | ELISA–RIA | 0.98 | – | – | – | 37 |
| ELISA–RGA | 0.99 | – | – | – | ||
| RIA–RGA | 0.97 | – | – | – | ||
| Infliximab | Promonitor ELISA–Sanquin ELISA | 0.98 | – | – | – | 38 |
| Infliximab | Promonitor ELISA V1–Promonitor ELISA V2 | – | – | 0.66 (0.32 to 0.83) | 1.58 (0.80 to 2.35) | 43 |
| Infliximab | Promonitor ELISA–ImmunoDiagnostic ELISA | – | 0.94 | – | 2.09 (1.41 to 2.77) | 39 |
| Infliximab | Leuven ELISA–Leuven FO-SPR | 0.998 | – | 0.98 (N/A) | – | 30 |
| Infliximab (CT-P13) | Matriks ELISA–Theradiag ELISA | – | 0.96 | – | – | 41 |
| Matriks ELISA–R-Biopharm ELISA | – | 0.86 | – | – | ||
| Theradiag ELISA–R-Biopharm ELISA | – | 0.92 | – | – | ||
| Adalimumab | Promonitor ELISA–Sanquin ELISA | 0.99 | – | – | – | 38 |
| Etanercept | Promonitor ELISA–Sanquin ELISA | 0.98 | – | – | – | 38 |
| Golimumab | Promonitor ELISA–Sanquin ELISA | – | 0.98 | – | −0.03 (−0.09 to 0.03) | 40 |
FO-SPR, fibre-optic surface plasmon resonance; HMSA, homogenous mobility shift assay; ICC, intraclass correlation coefficient; RGA, reporter gene assay; RIA, radioimmunoassay.