Original article—alimentary tractProspective Study of Motor, Sensory, Psychologic, and Autonomic Functions in Patients With Irritable Bowel Syndrome
Section snippets
Study Design and Participants
In a single-center, prospective study, 122 IBS patients (by Rome II criteria28) were recruited over a 4-year period; 119 were female and 3 (all in the IBS-D group) were male. Patients were recruited from an administrative database of 850 patients residing within 200 miles of the Mayo Clinic based on their primary presentation with IBS. Questionnaire responses assessed the coexistence of other gastrointestinal symptoms, psychologic disturbances, and the relationship of upper-abdominal symptoms
Participants
Participants' demographics and key psychologic data are shown in Table 1. IBS subgroups were similar in age. IBS-D and IBS-M patients had higher body mass index (BMI) values than healthy volunteers and IBS-C subjects. Physical examination (all performed by one experienced gastroenterologist [M.C.]) identified features suggestive of pelvic floor dysfunction in 12 patients: 5 with IBS-C, 2 with IBS-D, and 5 with IBS-M. All patients were referred to an evacuations disorder clinic and in 6 of 6 who
Discussion
In a group of predominantly female patients with IBS evaluated at a tertiary care center, abnormal colonic transit (32%) and rectal hyperalgesia (20.5%, increased sensory ratings) were the predominant disturbances of physiology, whereas the proportion with rectal hyposensitivity was 16.5%. These observations were based on patients characterized by bowel dysfunction and, particularly, abnormal functions were associated with endorsement of 1 to 4 primary IBS symptoms. In contrast, motor and
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Supported in part by grants RO1-DK54681 and K24-DK02638 to Dr. Camilleri from the National Institutes of Health. Dr. Low is supported in part by National Institutes of Health grants NS32352, NS44233, NS22352, and NS43364, and by Mayo funds. The studies were conducted in the Mayo Clinical Research Unit, which is supported by National Institutes of Health CTSA grant RR024150.
The excellent secretarial support of Mrs. Cindy Stanislav is gratefully acknowledged.