Rapid CommunicationsMethylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis☆,☆☆
Section snippets
Patients and methods
Consecutive patients with clinically inactive, long-standing UC (≥8 years) were recruited from the outpatient clinic of the First Department of Medicine at the University of Mainz (Mainz, Germany). Suitable patients were identified using the inclusion and exclusion criteria specified in Table 1.Inclusion criteria Clinically and histologically verified UC Disease duration ≥8 years Colitis Activity Index <8 Activity index of Truelove and Witts: mild Exclusion criteria Known
Patient demographics
A total of 263 consecutive patients with previously diagnosed UC from the outpatient clinic of the First Department of Medicine at the University of Mainz were screened for possible inclusion in the present study, 89 of whom were excluded (Figure 1).20A total of 174 patients fulfilled all inclusion criteria and were enrolled in the study, which was
Discussion
Long-standing UC is associated with a significantly increased risk for the development of intraepithelial neoplasias and colitis-associated carcinomas.3, 4, 5, 6 Only timely diagnosis of early neoplastic changes with serial surveillance colonoscopies allows preventive proctocolectomy in UC. However, the detection of early neoplastic lesions is challenging, even for the experienced endoscopist. In particular, only 20%-50% of intraepithelial neoplasias can be detected by routine colonoscopy.18
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Address requests for reprints to: Ralf Kiesslich, M.D., I. Med. Klinik und Poliklinik, Johannes Gutenberg Universität Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany. e-mail: [email protected]; fax: (49) 6131-175552.
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