Clinical—Alimentary TractClinical Features of Idiopathic Gastroparesis Vary With Sex, Body Mass, Symptom Onset, Delay in Gastric Emptying, and Gastroparesis Severity
Section snippets
Patients and Methods
The NIDDK Gastroparesis Clinical Research Consortium is a cooperative network of 7 clinical centers and one data coordinating center. The gastroparesis registry was implemented as an observational study of patients with gastroparesis (ClinicalTrials.gov identifier: NCT00398801). The registry consists of patients meeting specific entry criteria with symptoms of at least 12 weeks' duration, delayed gastric emptying on scintigraphy, and no abnormality causing obstruction on upper endoscopy.
Demographic Information
A total of 243 patients with IG were enrolled in the NIDDK registry at the time of data analysis (March 15, 2010). This represented 61% of the total number of patients with delayed gastric emptying enrolled (243 idiopathic, 131 diabetic, 27 other causes). Of the 243 patients with IG, 214 (88%) were female and 218 (90%) were white (Table 1). At the time of enrollment, the mean age was 41 ± 14 years; 30% were 30 years of age or younger. Mean body mass index (BMI) was 25.6 ± 6.9 kg/m2, with 8%
Discussion
This study highlights the clinical and physiologic features of patients with IG. The 243 patients in this multicenter report comprise the largest series of patients with IG. The study confirms that IG is a disease that particularly affects young women. Half of cases presented acutely, often in association with an initial infectious-like prodrome. The predominant symptom prompting evaluation was nausea in 34%, vomiting in 19%, and abdominal pain in 23%. Although the majority of patients were
Acknowledgments
Members of the Gastroparesis Clinical Research Consortium are listed in Supplementary Table 1.
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Conflicts of interest The authors disclose no conflicts.
Funding The Gastroparesis Clinical Research Consortium is supported by National Institute of Diabetes and Digestive and Kidney Diseases grants U01DK073983, U01DK073975, U01DK073985, U01DK074007, U01DK073974, and U01DK074008.