Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion

DM Reffitt, R Jugdaohsingh, RPH Thompson… - Journal of Inorganic …, 1999 - Elsevier
Silicon (Si), as silicic acid, is suggested to be the natural antidote to aluminium (Al) toxicity,
and was recently shown to promote the urinary excretion of Al from body stores. The …

HLA-DQA1–HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants

GA Heap, MN Weedon, CM Bewshea, A Singh… - Nature …, 2014 - nature.com
Pancreatitis occurs in approximately 4% of patients treated with the thiopurines azathioprine
or mercaptopurine. Its development is unpredictable and almost always leads to drug …

[HTML][HTML] Oligomeric but not monomeric silica prevents aluminum absorption in humans

R Jugdaohsingh, DM Reffitt, C Oldham, JP Day… - The American journal of …, 2000 - Elsevier
Background: Soluble silica, a ubiquitous component of the diet, may be the natural ligand for
dietary aluminum and may prevent its accumulation and toxicity in animals. However …

Bone density improves with disease remission in patients with inflammatory bowel disease

DM Reffitt, J Meenan, JD Sanderson… - European journal of …, 2003 - journals.lww.com
Results A total of 137 (64 ulcerative colitis, 73 Crohn's disease) patients were evaluated.
Patients in remission for more than three years had a normal mean Z-score that was …

Dedicated Barrett's surveillance sessions managed by trained endoscopists improve dysplasia detection rate

J Ooi, P Wilson, G Walker, P Blaker, S DeMartino… - …, 2017 - thieme-connect.com
Background and study aim Barrett's esophagus (BE)-associated dysplasia is an important
marker for risk of progression to esophageal adenocarcinoma (EAC) and an indication for …

Assessment of iron absorption from ferric trimaltol

DM Reffitt, TJ Burden, PT Seed… - Annals of clinical …, 2000 - journals.sagepub.com
Therapeutic iron compounds have limited absorption and often have side-effects, which
limits patient compliance. Iron trimaltol is a novel, stable complex, formed between ferric iron …

Intraductal fully covered self-expanding metal stents in the management of post-liver transplant anastomotic strictures: a UK wide experience

W Ahmed, D Kyle, A Khanna, J Devlin… - Therapeutic …, 2022 - journals.sagepub.com
Background: Fully covered intraductal self-expanding metal stents (IDSEMS) have been well
described in the management of post-liver transplant (LT) anastomotic strictures (ASs). Their …

Nasobiliary drainage: an effective treatment for pruritus in cholestatic liver disease

W Ahmed, R Jeyaraj, D Reffitt, J Devlin… - Frontline …, 2022 - fg.bmj.com
Introduction Nasobiliary drains (NBDs) have been successfully used to manage intrahepatic
cholestasis, bile leaks and obstructive cholangitis. It allows external drainage of bile …

Management of portal cavernoma-associated cholangiopathy: Single-centre experience

Y El-Sherif, P Harrison, K Courtney, D Lewis… - Clinics and Research in …, 2020 - Elsevier
Background and aims Portal cavernoma associated cholangiopathy (PCC) is an uncommon
disease in western countries. We describe our experience in seven patients with PCC, in …

[HTML][HTML] Anaemia investigation in practice: inappropriate, cost inefficient with a risk of missing gastrointestinal cancer. Can we improve?

S Mankodi, BH Hayee, J O'Donohue, D Reffitt - Clinical medicine, 2010 - ncbi.nlm.nih.gov
Iron-deficiency anaemia (IDA) is often inappropriately investigated. This study aimed to
improve referrals, estimate cost implications and determine effectiveness of referral criteria …