How can transforming growth factor beta be targeted usefully to combat liver fibrosis?
FW Shek, RC Benyon - European journal of gastroenterology & …, 2004 - journals.lww.com
Blockade of transforming growth factor beta (TGF-â) activity in vivo in animal models has
proven to be an effective means of inhibiting the fibrotic response to injury in various organs …
proven to be an effective means of inhibiting the fibrotic response to injury in various organs …
Pancreaticoduodenectomy for peri-ampullary neoplasia leads to specific micronutrient deficiencies
T Armstrong, L Strommer, F Ruiz-Jasbon, FW Shek… - Pancreatology, 2007 - Elsevier
Abstract Background/Aims: After pancreaticoduodenectomy (PD) patients may be deficient
in essential micronutrients. This study was designed to determine if this is a consequence of …
in essential micronutrients. This study was designed to determine if this is a consequence of …
The rise of Clostridium difficile: the effect of length of stay, patient age and antibiotic use
FW Shek, BSF Stacey, J Rendell, MD Hellier… - Journal of Hospital …, 2000 - Elsevier
Hospitals in the UK have recently seen a marked increase in C. difficile for reasons which
are unclear. Reduced standards of hygiene, increasingly elderly patients, greater …
are unclear. Reduced standards of hygiene, increasingly elderly patients, greater …
Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitis
WM Howell, PJ Pead, FW Shek… - Journal of clinical …, 2005 - jcp.bmj.com
Aims: To test the hypothesis that single nucleotide polymorphisms (SNPs) within genes (or
their promoter regions) encoding cytokines, growth factors, and intercellular adhesion …
their promoter regions) encoding cytokines, growth factors, and intercellular adhesion …
Transforming growth factor-beta3 (TGF-[beta] 3) expresses anti-fibrotic properties in pancreatic stellate cells
FW Shek, KF Li, J Mann, EJ Williams, JP Iredale… - Gut, 2004 - go.gale.com
Methods: Rat PSC were used in all experiments. Collagen secretion was determined using [.
sup. 3] H-Proline incorporation collagenase assay. Procollagen type 1 and TIMP-1 mRNA …
sup. 3] H-Proline incorporation collagenase assay. Procollagen type 1 and TIMP-1 mRNA …
Development of an integrated pancreatic disease service
JA Jupp, CD Johnson, FW Shek, DR Fine - Frontline Gastroenterology, 2011 - fg.bmj.com
An integrated pancreatic disease unit needs to deliver high-quality care both to patients with
malignant and non-malignant pancreatic disease. The regionalisation of pancreatic cancer …
malignant and non-malignant pancreatic disease. The regionalisation of pancreatic cancer …
A regional EUS service using a collaborative network
HM Gordon, DAJ Lloyd, A Higginson… - Frontline …, 2017 - fg.bmj.com
Endoscopic ultrasound (EUS) is increasingly used in the management of hepatobiliary
lesions, allowing staging and tissue acquisition. It is operator-dependent, and fine needle …
lesions, allowing staging and tissue acquisition. It is operator-dependent, and fine needle …
Insulin and IGF-1 inhibit pancreatic stellate cell apoptosis: Implications for resolution of fibrosis following pancreatic injury
Method: Rat PSCs were used between passages 2-4 and serum deprived prior to all
experiments. PSC were then treated with IGF-1 (1-100ng/ml) and insulin (1-10000ng/ml) …
experiments. PSC were then treated with IGF-1 (1-100ng/ml) and insulin (1-10000ng/ml) …
[CITATION][C] HBPD: Table of Contents Vol. 6, No. 1, 2007
J Permert, CD Johnson, E Tsiambas, A Karameris… - Pancreatology, 2007 - karger.com
Hepatobiliary & Pancreatic Diseases International (HBPD Int) Table of Contents Vol. 6, No. 1,
2007 Page 1 Hepatobiliary & Pancreatic Diseases International (HBPD Int) Table of Contents …
2007 Page 1 Hepatobiliary & Pancreatic Diseases International (HBPD Int) Table of Contents …
[CITATION][C] Autocrine up-regulation of CTGF by TGF-β1 in pancreatic stellate cell cultures: Implications for progressive fibrosis in chronic pancreatitis
FW Shek, EJ Williams, X Zhou - Pancreatology, 2001