The proper functioning of the adult mammalian brain relies on the orchestrated regulation of
neural activity by a diverse population of GABA (γ-aminobutyric acid)-releasing neurons …

N-methyl-d-aspartate receptors (NMDARs) are present at many excitatory glutamate
synapses in the central nervous system and display unique properties that depend on their …

AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory synaptic
transmission in the brain. Diversity in excitatory signalling arises, in part, from functional …

Neuroactive steroids are potent modulators of γ-aminobutyric acid type A receptors
(GABAARs), and their behavioral effects are generally viewed in terms of altered inhibitory …

1. To investigate the origin and functional significance of a recently described tonic GABAA
receptor‐mediated conductance in cerebellar granule cells we have made recordings from …

Many neurons receive a continuous, or 'tonic', synaptic input, which increases their
membrane conductance, and so modifies the spatial and temporal integration of excitatory …

In many neurons, responses to individual quanta of transmitter exhibit large variations in
amplitude. The origin of this variability, although central to our understanding of synaptic …

GABA A receptors mediate fast synaptic inhibition in the CNS. Whilst this is undoubtedly
true, it is a gross oversimplification of their actions. The receptors themselves are diverse …

Although feedforward inhibition onto Purkinje cells was first documented 40 years ago, we
understand little of how inhibitory interneurons contribute to cerebellar function in behaving …

Susceptibility to autoimmune hepatitis in white patients is associated with the human
leukocyte antigen class II antigens DR3 and DR4. To analyze the molecular basis of these …