Constraining cyclic peptides to mimic protein structure motifs

TA Hill, NE Shepherd, F Diness… - Angewandte Chemie …, 2014 - Wiley Online Library
Many proteins exert their biological activities through small exposed surface regions called
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …

Orally absorbed cyclic peptides

DS Nielsen, NE Shepherd, W Xu, AJ Lucke… - Chemical …, 2017 - ACS Publications
Peptides and proteins are not orally bioavailable in mammals, although a few peptides are
intestinally absorbed in small amounts. Polypeptides are generally too large and polar to …

The influence of context on the strategic decision‐making process: A review of the literature

NG Shepherd, JM Rudd - International journal of management …, 2014 - Wiley Online Library
This paper critically reviews the strategic decision‐making process literature, with a specific
focus on the effects of context. Context refers to the top management team, strategic decision …

[HTML][HTML] Raman spectroscopy: elucidation of biochemical changes in carcinogenesis of oesophagus

G Shetty, C Kendall, N Shepherd, N Stone… - British journal of …, 2006 - nature.com
Several techniques are under development to diagnose oesophageal adenocarcinoma at
an earlier stage. We have demonstrated the potential of Raman spectroscopy, an optical …

European consensus on the histopathology of inflammatory bowel disease

F Magro, C Langner, A Driessen… - Journal of Crohn's …, 2013 - academic.oup.com
The histologic examination of endoscopic biopsies or resection specimens remains a key
step in the work-up of affected inflammatory bowel disease (IBD) patients and can be used …

Near‐infrared Raman spectroscopy for the classification of epithelial pre‐cancers and cancers

N Stone, C Kendall, N Shepherd… - Journal of Raman …, 2002 - Wiley Online Library
The use of near‐infrared Raman spectroscopy to interrogate epithelial tissue biochemistry
and hence distinguish between normal and abnormal tissues was investigated. Six different …

Consensus statements for management of Barrett's dysplasia and early-stage esophageal adenocarcinoma, based on a Delphi process

…, K Ragunath, J Regula, R Cestari, N Shepherd… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Esophageal adenocarcinoma (EA) is increasingly common among
patients with Barrett's esophagus (BE). We aimed to provide consensus recommendations …

Rapid changes in microRNA-146a expression negatively regulate the IL-1β-induced inflammatory response in human lung alveolar epithelial cells

MM Perry, SA Moschos, AE Williams… - The Journal of …, 2008 - journals.aai.org
Posttranscriptional regulation of gene expression by microRNAs (miRNAs) has been
implicated in the regulation of chronic physiological and pathological responses. In this …

British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma

…, MR Novelli, K Ragunath, N Shepherd… - Gut, 2019 - gut.bmj.com
Gastric adenocarcinoma carries a poor prognosis, in part due to the late stage of diagnosis.
Risk factors include Helicobacter pylori infection, family history of gastric cancer—in …

Deep learning for prediction of colorectal cancer outcome: a discovery and validation study

OJ Skrede, S De Raedt, A Kleppe, TS Hveem, K Liestøl… - The Lancet, 2020 - thelancet.com
Background Improved markers of prognosis are needed to stratify patients with early-stage
colorectal cancer to refine selection of adjuvant therapy. The aim of the present study was to …