Constraining cyclic peptides to mimic protein structure motifs
Many proteins exert their biological activities through small exposed surface regions called
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …
Orally absorbed cyclic peptides
DS Nielsen, NE Shepherd, W Xu, AJ Lucke… - Chemical …, 2017 - ACS Publications
Peptides and proteins are not orally bioavailable in mammals, although a few peptides are
intestinally absorbed in small amounts. Polypeptides are generally too large and polar to …
intestinally absorbed in small amounts. Polypeptides are generally too large and polar to …
The influence of context on the strategic decision‐making process: A review of the literature
NG Shepherd, JM Rudd - International journal of management …, 2014 - Wiley Online Library
This paper critically reviews the strategic decision‐making process literature, with a specific
focus on the effects of context. Context refers to the top management team, strategic decision …
focus on the effects of context. Context refers to the top management team, strategic decision …
[HTML][HTML] Raman spectroscopy: elucidation of biochemical changes in carcinogenesis of oesophagus
Several techniques are under development to diagnose oesophageal adenocarcinoma at
an earlier stage. We have demonstrated the potential of Raman spectroscopy, an optical …
an earlier stage. We have demonstrated the potential of Raman spectroscopy, an optical …
European consensus on the histopathology of inflammatory bowel disease
F Magro, C Langner, A Driessen… - Journal of Crohn's …, 2013 - academic.oup.com
The histologic examination of endoscopic biopsies or resection specimens remains a key
step in the work-up of affected inflammatory bowel disease (IBD) patients and can be used …
step in the work-up of affected inflammatory bowel disease (IBD) patients and can be used …
Near‐infrared Raman spectroscopy for the classification of epithelial pre‐cancers and cancers
The use of near‐infrared Raman spectroscopy to interrogate epithelial tissue biochemistry
and hence distinguish between normal and abnormal tissues was investigated. Six different …
and hence distinguish between normal and abnormal tissues was investigated. Six different …
Consensus statements for management of Barrett's dysplasia and early-stage esophageal adenocarcinoma, based on a Delphi process
…, K Ragunath, J Regula, R Cestari, N Shepherd… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Esophageal adenocarcinoma (EA) is increasingly common among
patients with Barrett's esophagus (BE). We aimed to provide consensus recommendations …
patients with Barrett's esophagus (BE). We aimed to provide consensus recommendations …
Rapid changes in microRNA-146a expression negatively regulate the IL-1β-induced inflammatory response in human lung alveolar epithelial cells
MM Perry, SA Moschos, AE Williams… - The Journal of …, 2008 - journals.aai.org
Posttranscriptional regulation of gene expression by microRNAs (miRNAs) has been
implicated in the regulation of chronic physiological and pathological responses. In this …
implicated in the regulation of chronic physiological and pathological responses. In this …
British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma
…, MR Novelli, K Ragunath, N Shepherd… - Gut, 2019 - gut.bmj.com
Gastric adenocarcinoma carries a poor prognosis, in part due to the late stage of diagnosis.
Risk factors include Helicobacter pylori infection, family history of gastric cancer—in …
Risk factors include Helicobacter pylori infection, family history of gastric cancer—in …
Deep learning for prediction of colorectal cancer outcome: a discovery and validation study
OJ Skrede, S De Raedt, A Kleppe, TS Hveem, K Liestøl… - The Lancet, 2020 - thelancet.com
Background Improved markers of prognosis are needed to stratify patients with early-stage
colorectal cancer to refine selection of adjuvant therapy. The aim of the present study was to …
colorectal cancer to refine selection of adjuvant therapy. The aim of the present study was to …