The abc of apc

NS Fearnhead, MP Britton… - Human molecular …, 2001 - academic.oup.com
Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease
characterized by the presence of adenomatous polyps in the colon and rectum, with …

Genetics of colorectal cancer: hereditary aspects and overview of colorectal tumorigenesis

NS Fearnhead, JL Wilding, WF Bodmer - British medical bulletin, 2002 - academic.oup.com
Familial adenomatous polyposis and hereditary non-polyposis colorectal cancer are
dominantly inherited conditions with 100% and 80% life-time risk of developing colorectal …

Impact of ileal pouch-anal anastomosis on female fertility: meta-analysis and systematic review

SG Rajaratnam, TW Eglinton, P Hider… - International journal of …, 2011 - Springer
Purpose The aim of this review is to determine the effect of ileal pouch-anal anastomosis
(IPAA) on female fertility in ulcerative colitis (UC) and familial adenomatous polyposis (FAP) …

International consensus definition of low anterior resection syndrome

C Keane, NS Fearnhead, L Bordeianou… - Colorectal …, 2020 - Wiley Online Library
Aim Low anterior resection syndrome (LARS) is pragmatically defined as disordered bowel
function after rectal resection leading to a detriment in quality of life. This broad …

Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas

NS Fearnhead, JL Wilding, B Winney… - Proceedings of the …, 2004 - National Acad Sciences
Clear-cut inherited Mendelian traits, such as familial adenomatous polyposis or hereditary
nonpolyposis colorectal cancer, account for< 4% of colorectal cancers. Another 20% of all …

Developing a core outcome set for fistulising perianal Crohn's disease

K Sahnan, PJ Tozer, SO Adegbola, MJ Lee… - Gut, 2019 - gut.bmj.com
Objective Lack of standardised outcomes hampers effective analysis and comparison of
data when comparing treatments in fistulising perianal Crohn's disease (pCD). Development …

Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer

M Lawler, D Alsina, RA Adams, AS Anderson, G Brown… - Gut, 2018 - gut.bmj.com
Objective Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide.
Defining critical research gaps (RG), their prioritisation and resolution, could improve patient …

Effect of public reporting of surgeons' outcomes on patient selection,“gaming,” and mortality in colorectal cancer surgery in England: population based cohort study

AE Vallance, NS Fearnhead, A Kuryba, J Hill… - bmj, 2018 - bmj.com
Objective To determine the effect of surgeon specific outcome reporting in colorectal cancer
surgery on risk averse clinical practice,“gaming” of clinical data, and 90 day postoperative …

What is the impact of hospital and surgeon volumes on outcomes in rectal cancer surgery?

JM Boyle, J van der Meulen, A Kuryba… - Colorectal …, 2023 - Wiley Online Library
Aim Evidence for a positive volume–outcome relationship for rectal cancer surgery is
unclear. This study aims to evaluate the volume–outcome relationship for rectal cancer …

[HTML][HTML] Surgical treatment and outcomes of colorectal cancer patients during the COVID-19 pandemic: a national population-based study in England

A Kuryba, JM Boyle, HA Blake, A Aggarwal… - Annals of Surgery …, 2021 - journals.lww.com
Objective: To compare the management and outcomes of colorectal cancer (CRC) patients
during the first 2 months of the COVID-19 pandemic with the preceding 6 months …