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Guideline review
Guideline review: British Society of Gastroenterology/UK-PBC Primary Biliary Cholangitis treatment and management guidelines
  1. Jorn C Goet1,
  2. Gideon M Hirschfield2
  1. 1 Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands
  2. 2 Toronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, Ontario, Canada
  1. Correspondence to Professor Gideon M Hirschfield, Toronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, ON M5G 2C4, Canada; gideon.hirschfield{at}


New guidelines have been produced for the management of primary biliary cholangitis, an infrequent but nonetheless important autoimmune liver disease. We provide a succient commentary and overview of the key features of disease management that arise from these recent guideline recommendations, with a focus on therapy with licensed agents (ursodeoxycholic acid and obeticholic acid) as well as personalised management of disease complications and associated symptoms.

  • cholestasis
  • primary biliary cirrhosis
  • ursodeoxycholic acid
  • obeticholic acid

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  • Contributors Drafting the manuscript: JCG. Drafting and revising the manuscript critically for important intellectual content: GMH.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests GMH has consulted for GSK, Novartis, Cymabay, Intercept, Falk, Gilead.

  • Provenance and peer review Not commissioned; externally peer reviewed.