You are here

Article Text

Article menu
Download PDFPDF
Highlights from the literature
Highlights from the literature
  1. Rafeeq Muhammed
  1. Department of Paediatric Gastroenterology, Birmingham Children’s Hospital, Birmingham, UK
  1. Correspondence to Dr Rafeeq Muhammed; rafeeq.muhammed{at}nhs.net

https://doi.org/10.1136/flgastro-2019-101219

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Risk of developing coeliac disease is low for children with potential coeliac disease

    The CELIPREV (Celiac Disease Risk Prevalence and natural history of potential celiac disease in at family-risk infants prospectively investigated from birth) study1 prospectively followed up 553 children in Italy from birth with coeliac disease (CD)–predisposing human leucocyte antigen (HLA) genes. Children with a diagnosis of potential CD continued to receive a normal diet and repeated the serological screening for CD every year. Potential CD was defined in the presence of (1) a CD-compatible HLA genotype, (2) a Marsh 0–1 lesion at the biopsy, and (3) IgA tissue transglutaminase antibody and endomysial antibody positivity or IgG tissue transglutaminase antibody positivity in presence of IgA deficiency. A small-intestinal biopsy was taken in presence of persistent positive serology. Overall, 26 (4.7%) children received a diagnosis of potential CD (50% females, median age 24 months). All children were symptom-free. Twenty-three …

    View Full Text

    Footnotes

    • Contributors I am the sole contributor to this manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Commissioned; externally peer reviewed.