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Risk of developing coeliac disease is low for children with potential coeliac disease
The CELIPREV (Celiac Disease Risk Prevalence and natural history of potential celiac disease in at family-risk infants prospectively investigated from birth) study1 prospectively followed up 553 children in Italy from birth with coeliac disease (CD)–predisposing human leucocyte antigen (HLA) genes. Children with a diagnosis of potential CD continued to receive a normal diet and repeated the serological screening for CD every year. Potential CD was defined in the presence of (1) a CD-compatible HLA genotype, (2) a Marsh 0–1 lesion at the biopsy, and (3) IgA tissue transglutaminase antibody and endomysial antibody positivity or IgG tissue transglutaminase antibody positivity in presence of IgA deficiency. A small-intestinal biopsy was taken in presence of persistent positive serology. Overall, 26 (4.7%) children received a diagnosis of potential CD (50% females, median age 24 months). All children were symptom-free. Twenty-three …
Contributors I am the sole contributor to this manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Commissioned; externally peer reviewed.
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