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Diagnosis and management of catheter-related bloodstream infections in patients on home parenteral nutrition
  1. Ashley Bond1,
  2. Paul Chadwick2,
  3. Trevor R Smith3,
  4. Jeremy M D Nightingale4,
  5. Simon Lal1
  1. 1 Intestinal Failure Unit, Salford Royal NHS Foundation Trust, Salford, UK
  2. 2 Microbiology, Salford Royal NHS Foundation Trust, Salford, UK
  3. 3 Gastroenterology, University Hospital Southampton NHS Foundation Trusts, Southampton, UK
  4. 4 Gastroenterology, St Marks Hospital, Harrow, UK
  1. Correspondence to Dr Ashley Bond, Intestinal failure unit, Salford Royal Foundation Trust, Salford M6 8HD, UK; ashleybond{at}


Catheter-related bloodstream infections (CRBSIs) commonly arise from a parenteral nutrition catheter hub. A target for a Nutrition Support Team is to have a CRBSI rate of less than 1 per 1000. The diagnosis of CRBSI is suspected clinically by a temperature shortly after setting up a feed, general malaise or raised blood inflammatory markers. It is confirmed by qualitative and quantitative blood cultures from the catheter and peripherally. Treatment of inpatients may involve central venous catheter removal and antibiotics for patients needing short-term parenteral nutrition, but catheter salvage is generally recommended for patients needing long-term parenteral nutrition, where appropriate.

  • catheter related blood stream infection
  • parenteral nutrition
  • intestinal failure

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  • Contributors AB and SL planned and drafted the manuscript. PC, TRS and JMDN reviewed and contributed to the manuscript, reviewing before submission.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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