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Paediatric cholestatic liver disorders for the adult gastroenterologist: a practical guide
  1. Claire Kelly,
  2. Jeremy Shanika Nayagam,
  3. Stamatina Vogli,
  4. Marianne Samyn,
  5. Deepak Joshi
  1. Institute of Liver Studies, King's College Hospital, London, UK
  1. Correspondence to Dr Claire Kelly, Institute of Liver Studies, King's College Hospital, London SE5 9RS, UK; clairekelly4{at}


With improvements in the outcomes for cholestatic liver diseases that present in childhood, increasing numbers of patients will require ongoing care as adults. The recent advances in management options coupled with the fact that each adult physician will have a limited number of patients with these conditions means there is a need for those in adult services to develop expertise in these conditions that were historically the domain of paediatrics. This review provides an overview of the most common paediatric cholestatic liver diseases and outlines the clinical manifestations and potential complications, and identifies key management issues unique to each condition for effective ongoing care of these patients.

  • cholestasis
  • cholestatic liver diseases
  • paediatric liver disease

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  • Contributors CK, MS, DJ: conceptualisation of the work and designed the manuscript, drafted the work and revised it critically, reviewed and edited the final version. CK, JSN, SV: carried out the literature review, drafted the work, revised it critically, reviewed and edited the final version.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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