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OC3 Rising incidence of paediatric inflammatory bowel disease in South Wales, United Kingdom
  1. Z Green1,
  2. JJ Ashton2,3,
  3. E Trow1,
  4. G Petty1,
  5. C Court1,
  6. J Girvin1,
  7. M Edwards1,
  8. J Chan1,
  9. RM Beattie2,
  10. A Wahid1
  1. 1Noah’s Ark Children’s Hospital for Wales, Cardiff and Vale University Health Board, Heath Park Way, Cardiff, CF14 4XW, UK
  2. 2University Hospital Southampton, Tremona Way, Southampton, England SO16 6YD, UK
  3. 3Human Genetics and Genomic Medicine, University of Southampton, Southampton, England SO16 6YD, UK

Abstract

Rates of paediatric inflammatory bowel disease (pIBD) have increased globally over the last 25 years. In South Wales, incidence was last reported for 1998–2003 (5.4/100,000),1 and subsequent defined national and global cohorts have described increases, particularly in Crohn’s disease. This work aimed to characterise and update the contemporary incidence of pIBD in South Wales, highlighting implications for resource planning in paediatric and adult gastroenterology services across the region.

Data from the paediatric gastroenterology tertiary referral centre retrospective/prospective pIBD database were retrieved for 2011–2021. Data were classified by age at diagnosis, gender and type of IBD (IBDU, CD, UC). At risk population (<18 years) was determined using 2011 and 2021 UK census data.2 3 Population numbers were extrapolated between censuses. Potential differences in age at diagnosis were analysed though ANOVA. Pearson’s correlation coefficients were calculated for analysis of total IBD, UC and Crohn’s incidence by year.

365 patients were included (mean age at diagnosis 12.7, 37.3% female). There were no differences in age at diagnosis over the ten-year period as assessed by ANOVA (F=1.629, p=0.097). Total incidence rose from 2011 (4.28/100,000) to 2018 (6.93/100,000) and again to 2021 (11.24/100,000), β=0.9, p=0.000157 (table 1). Male pIBD increased from 5.57/100,000 in 2011 to 14.01/100,000 in 2021 and female pIBD increased from 2.29/100,000 to 8.32/100,000.

The largest increase was seen in Crohn’s disease from 2011 (2.85/100,000) to 2021 (8.29/100,000), β=0.8, p=0.03. Ulcerative Colitis incidence did not significantly increase, at 1.43/100,000 in 2011 and 2.76/100,000 in 2021, β=0.46, p=0.154.

The incidence of pIBD continues to rise across South Wales, with increases in affected males and those with Crohn’s disease. This is in keeping with contemporary trends. Increases are likely driven by multifactorial environmental triggers and highlight continued need to map incidence. These ongoing increases represent significant implications for services.

View this table:
Abstract OC3 Table 1

Mean age at diagnosis and incidence rates per 100,000 by year for 2011 to 2021

References

  1. Ahmed M, Davies IH, Hood K, Jenkins HR. Incidence of paediatric inflammatory bowel disease in South Wales. Arch Dis Child. 2006 Apr;91(4):344–5.

  2. Anon. Office for National Statistics - Census 2011. https://gov.wales/census-population-2011. 2012.

  3. Anon. Office for National Statistics - Census 2021. https://gov.wales/population-and-household-estimates-wales-census-2021. 2022.

https://doi.org/10.1136/flgastro-2023-bspghan.3

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