Protein losing enteropathy (PLE) is a complication of various intestinal disorders characterised by an excessive loss of protein into the gastrointestinal tract. It can be a rare complication of severe iron deficiency anaemia due to excess cow’s milk intake. There is a lack of GI symptoms with oedema as main presenting feature. Therefore diagnosis may be missed if clinical suspicion is low and stool Alpha1 Antitrypsin (A1AT) levels are not sent. We describe a case series of 3 toddlers who presented with oedema and were found to have severe iron deficiency anaemia due to excess cow’s milk in the diet. Case 1: 17 month old girl presented with 3-week history of tiredness and pallor. She had periorbital oedema a week before presentation. There was no history of diarrhoea. Dietary history revealed excess milk intake of 800 mls a day. Serum albumin was low without any proteinuria and normal liver function. Case 2: 13 month old girl presented with 4-day history of oedema. She was breast fed till 12 months of age. She was drinking cow’s milk for the previous few weeks and was taking 900 mls per day. She had low serum albumin with no proteinuria. Case 3: 13-month-old, presented with periorbital swelling for 2 weeks and was found to be anaemic. Bloods parameters were not typical of iron deficiency but she had low serum albumin. She had normocytic, hypochromic anaemia with pencil cell and acanthocytes in blood film. Because of concerns regarding malabsorption and diagnostic uncertainty, micronutrients and vitamin levels were checked along with stool A1AT. Copper and Zinc levels were found to be low. She was given supplementation for a month. The blood film then became typical of Fe deficiency. All 3 children needed a blood transfusion and were started on iron supplements. It was remarkable that none had diarrhoea. Stool A1AT was high in all patients indicating a PLE. All 3 children had low immunoglobulins. Cow’s milk intake varied from 700–900 mls a day. One child had a micronutrient deficiency (Cu and Zn) which masked the Fe deficiency and caused concerns about the diagnosis. However, a typical picture of Fe deficiency evolved once micronutrient deficiency was treated. PLE resolved within 8 weeks of treatment with iron supplements and reducing milk intake. In children presenting with oedema and severe Iron deficiency, dietary history of excess cow’s milk intake must raise a clinical suspicion of PLE. Stool A1AT should be sent in these cases to avoid more invasive investigations. Dietary history is crucial as literature suggests that more than 16 oz of Cow’s milk per day (480 ml) can cause Iron deficiency and PLE. Micronutrient deficiency may be seen in severe PLE and may mask Fe deficiency. The exact mechanism of PLE is not known in Fe deficiency but it is not associated with hypersensitivity to cow’s milk protein.