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Liver
Systematic review
Liver outcomes following proctocolectomy in patients with primary sclerosing cholangitis and ulcerative colitis
  1. Thomas Ryan1,
  2. Jonathan P Segal2,3
  1. 1 The University of Melbourne Medical School, Parkville, Victoria, Australia
  2. 2 The Royal Melbourne Hospital City Campus, Parkville, Victoria, Australia
  3. 3 Department of Medicine, University of Medicine, Parkville, Victoria, Australia
  1. Correspondence to Thomas Ryan, The University of Melbourne Melbourne Medical School, Parkville, Victoria, Australia; tplryan1999{at}gmail.com

Abstract

Background The aims of this narrative review are to examine the impact of proctocolectomy on the liver in patients with primary sclerosing cholangitis and ulcerative colitis (PSC-UC), mainly focusing on graft loss, and to compare the different proctocolectomy techniques to help determine which is the best for PSC-UC patients.

Methods A literature search was performed using the online databases MEDLINE and Embase. Studies found via the search were evaluated against both inclusion and exclusion criteria by two independent reviewers (TR and JS). Relevant studies were included in the review.

Results Seven studies were deemed relevant through the literature search and review process and another one was included via other sources, therefore, eight studies were included in the final review.

Conclusions Proctocolectomy does not appear to have a negative impact on the liver and ileostomy appears to have better outcomes in terms of graft loss compared with ileal pouch-anal anastomosis. However, more high-quality studies on this topic are required as the existing literature is limited, and therefore, the findings should not be overinterpreted.

  • PRIMARY SCLEROSING CHOLANGITIS
  • ULCERATIVE COLITIS
  • INFLAMMATORY BOWEL DISEASE

Data availability statement

Data is available upon request.

https://doi.org/10.1136/flgastro-2023-102600

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    Data availability statement

    Data is available upon request.

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    Footnotes

    • Contributors TR: whole manuscript preparation, literature searching, analysis and write up. JS: literature searching, review of manuscript, guarantor.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.

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