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To biopsy or not to biopsy (for the diagnosis of coeliac disease): insights from the #FGDebate
  1. Giovanna McGinty1,
  2. Suneil A Raju2,3,
  3. David Surendran Sanders2,3,
  4. Peter Michael Gillett4
  1. 1 Gastroenterology, North Bristol NHS Trust Southmead Hospital, Bristol, UK
  2. 2 Academic Unit of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
  3. 3 Division of Clinical Medicine, The University of Sheffield Medical School, Sheffield, UK
  4. 4 Paediatric Gastroenterology and Nutrition Department, RHCYP, Edinburgh, UK
  1. Correspondence to Dr Giovanna McGinty, Gastroenterology, North Bristol NHS Trust Southmead Hospital, Bristol, UK; mcgintygio{at}gmail.com

https://doi.org/10.1136/flgastro-2024-102640

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    The September 2023 Frontline Gastroenterology Twitter Debate (#FGDebate) focused on the safety of a no-biopsy approach to diagnosing coeliac disease (CD) for those with elevated transglutaminase IgA antibody titres (TTG-IgA). This was based on a paper published in Frontline Gastroenterology in August 2022 by Hoyle et al.1 Box 1 summarises out quick facts that arose from the debate and box 2 summarises key points from the British Society of Gastroenterology (BSG) guidance which were explored in the debate.

    Box 1

    Coeliac disease biopsy quick facts

    • A no-biopsy approach allows for CD to be diagnosed in patients using serology only.

    • There is growing UK data that a TTG-IgA level greater than 10x the upper limit of normal can be used in patients …

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    Footnotes

    • X @sheiybani

    • Contributors GM wrote the main draft of the manuscript. SAR, DSS and PMG reviewed and edited the manuscript. All authors approved the final version of the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests GM is a trainee associate editor for Frontline Gastroenterology.

    • Provenance and peer review Not commissioned; internally peer reviewed.

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