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Cryptogenic colitis due to occult cytomegalovirus infection
  1. Daniel J B Marks1,2,
  2. Philip J Smith1,2,
  3. Farooq Z Rahman1,2,
  4. Robert F Miller3,
  5. Jonathan A Ledermann4,
  6. Stuart L Bloom2
  1. 1Department of Medicine, University College London, London, UK
  2. 2Department of Gastroenterology, University College London Hospital, London, UK
  3. 3Research Department of Infection and Population Health, University College London, London, UK
  4. 4Department of Oncology, University College London Hospital, London, UK
  1. Correspondence to Dr D J B Marks, Centre for Molecular Medicine, Rayne Institute, 5 University Street, London WC1E 6JJ, UK; d.marks{at}


Colitis secondary to cytomegalovirus infection is well recognised and usually straightforward to diagnose. Here two cases are reported in whom all initial investigations failed to demonstrate the presence of virus, with potential adverse consequences for its treatment. A case is made for empirical antiviral therapy despite negative investigations if clinical suspicion is high.

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  • DJBM and PJS contributed equally to this work.

  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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