Article Text

Epstein–Barr virus infection and central nervous system involvement after orthoptic liver transplant
  1. Kamran Shafiq1,
  2. Ahamad Hassan2,
  3. Mervyn H Davies3,
  4. Rebecca L Jones3
  1. 1City Hospitals Sunderland, Sunderland, UK
  2. 2Department of Neurology, Leeds General Infirmary, Leeds, UK
  3. 3Liver Transplant Unit, St James's University Hospital, Leeds, UK
  1. Correspondence to Kamran Shafiq, Consultant Gastroenterologist, City Hospitals Sunderland, Kayll Road, Sunderland SR4 7TP, UK; kshafiq2003{at}


Epstein–Barr virus (EBV) infection presenting as encephalitis in seronegative adults in the context of solid organ transplantation is rarely reported. EBV seroconversion illnesses in the adult population after organ transplantation are quite uncommon. This report describes a case of encephalitis due to EBV infection after liver transplantation in an adult patient. The patient was seronegative for EBV pretransplant. She showed persistent viral replication indicated by high levels of EBV DNA in the serum, which raised concerns for future development of post-transplant lymphoproliferative disorder. The report discusses the management of such patients, awareness of EBV infection and earlier diagnosis by use of EBV PCR in adult immunocompromised individuals where infection may cause particular problems.

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  • Provenance and peer review Not commissioned; externally peer reviewed.

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