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Parenteral methotrexate for patients with Crohn's disease: how to develop a high-quality and safe self-administration service
  1. Iona Coltart1,
  2. Laura Blackmore1,
  3. Jane Caisley2,
  4. Adam Harris1
  1. 1Department of Gastroenterology, The Tunbridge Wells Hospital, Tunbridge Wells, UK
  2. 2Department of Pharmacy, The Tunbridge Wells Hospital, Tunbridge Wells, UK
  1. Correspondence to Iona Coltart, Department of Gastroenterology, The Tunbridge Wells Hospital, Tonbridge Road, Pembury, Tunbridge Wells, Kent, TN2 4QJ; iona.coltart{at}


Parenteral methotrexate is recommended for patients with Crohn's disease who have failed treatment with thiopurines. There is no good evidence for the use of oral methotrexate, yet patients frequently receive this due to the difficulties associated with prescribing and administering an unlicensed, cytotoxic drug.

We present our experience of developing a local service to provide our patients with the option to self-administer parenteral methotrexate in a safe and structured manner at home.

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  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.