Article Text

Curriculum based clinical reviews
Pregnancy-associated liver disease: a curriculum-based review
  1. Claire Kelly1,2,
  2. Marinos Pericleous1,2
  1. 1 Department of Gastroenterology and Hepatology, Royal Surrey County Hospital, Guildford, UK
  2. 2 Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK
  1. Correspondence to Dr Claire Kelly; clairekelly4{at}


Pregnancy is associated with changes in normal physiology, including changes to the normal parameters for blood tests. Abnormal liver function tests are a common reason for referral to gastroenterology. However, in the pregnant patient, there are unique potential causes. It is of prime importance to be aware of pregnancy-specific liver diseases as they can be serious and progress rapidly affecting outcomes for both the mother and fetus. Here, we provide an overview of the manifestations of pregnancy-related liver diseases and discuss their potential consequences.

  • liver disease in pregnancy
  • acute fatty liver

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  • Contributors Both authors were involved in the conceptualisation of the work and designed the manuscript, carried out the literature review, drafted the work and revised it critically for important intellectual content. Both authors provided final approval of the version to be published and agreed to be accountable for the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

  • Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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