The two main drugs used in the treatment of gastro-oesophageal reflux disease are proton pump inhibitors and histamine-2 receptor antagonists and both these agents have been implicated in a number of adverse effects, leading to considerable controversies related to their long-term use. This paper is aimed at a critical review of the published literature and the clinical significance of these reported side effects, most of which are associations rather than causal.
- acid-related diseases
- adverse drug reactions
- gastroesophageal reflux disease
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Contributors AD, HJD and FM all contributed to the writing of the manuscript. AD revised the manuscript and is the senior author. SA provided a critique and contributed suggestions for improvement. AD is responsible for the overall content and is guarantor for the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Commissioned; externally peer reviewed.