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Guideline review
European Guideline on IgG4-related digestive disease: UEG and SGF evidence-based recommendations
  1. Wei On,
  2. Matthew T Huggett
  1. Department of Gastroenterology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
  1. Correspondence to Dr Wei On, Department of Gastroenterology, Leeds Teaching Hospitals NHS Trust, Leeds LS9 7TF, UK; weiheng.on{at}


Immunoglobulin subclass 4 related disease (IgG4-RD) is an increasingly recognised autoimmune disease with the potential of affecting various organs. It has a predilection for certain anatomical hotspots and the pancreatobiliary tract is the the most common area involved. Due to the relative novelty of IgG4-RD, the understanding of the disease process continues to involve. Recent European guidelines on IgG4-RD have been published by a working group collaboration between the United European Gastroenterology and Swedish Society of Gastroenterology. In our commentary, we aim to extract the key practical points with an emphasis on diagnosis and management of IgG4-RD with specific focus on the pancreatobiliary tract.

  • autoimmune biliary disease
  • pancreatic disorders
  • hepatobiliary disease

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  • Contributors MTH proposed conception of the manuscript and critically revised the manuscript. WO conducted the guideline review and wrote the initial draft. Both authors approved of the final version. MTH is the guarantor for the overall content of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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