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Original research
Satellite liver transplant centres significantly improve transplant assessment outcomes for patients with chronic liver disease but not hepatocellular carcinoma: a retrospective cohort study
  1. Oliver D Tavabie1,
  2. Victoria T Kronsten1,
  3. Robert Przemioslo2,
  4. Neil McDougall3,
  5. Katie Ramos4,
  6. Deepak Joshi1,
  7. Andreas Prachalias1,
  8. Krish Menon1,
  9. Kosh Agarwal1,
  10. Michael A Heneghan1,
  11. Talal Valliani2,
  12. Johnny Cash3,
  13. Matthew E Cramp4,
  14. Varuna Aluvihare1
  1. 1Institute of Liver Studies, King's College Hospital, London, UK
  2. 2Department of Gastroenterology, North Bristol NHS Trust, Bristol, UK
  3. 3The Liver Unit, Royal Victoria Hospital, Belfast, UK
  4. 4South West Liver Unit, Plymouth Hospitals NHS Trust, Plymouth, UK
  1. Correspondence to Varuna Aluvihare; varuna.aluvihare{at}kcl.ac.uk

Abstract

Introduction Liver transplantation (LT) remains integral to the management of end-stage chronic liver disease (CLD). However, referral thresholds and assessment pathways remain poorly defined. Distance from LT centre has been demonstrated to impact negatively on patient outcomes resulting in the development of satellite LT centres (SLTCs). We aimed to evaluate the impact of SLTCs on LT assessment in patients with CLD and hepatocellular carcinoma (HCC).

Methods A retrospective cohort study was undertaken including all patients with CLD or HCC assessed for LT at King’s College Hospital (KCH) between October 2014 and October 2019. Referral location, social, demographic, clinical and laboratory data were collected. Univariable and multivariable analyses (MVA) were performed to assess the impact of SLTCs on patients being accepted as LT candidates and contraindications being identified.

Results 1102 and 240 LT assessments were included for patients with CLD and HCC, respectively. MVA demonstrated significant associations with; patients living greater than 60 min from KCH/SLTCs and LT candidacy acceptance in CLD, and less deprived patients and LT candidacy acceptance in HCC. However, neither variable was associated with identification of LT contraindications. MVA demonstrated that referrals from SLTCs were more likely to result in acceptance of LT candidacy and less likely to result in a contraindication being identified in CLD. However, such associations were not demonstrated in HCC.

Conclusion SLTCs improve LT assessment outcomes in CLD but not HCC reflecting the standardised HCC referral pathway. Developing a formal regional LT assessment pathway across the UK would improve equity of access to transplantation.

  • alcoholic liver disease
  • cirrhosis
  • health service research
  • hepatocellular carcinoma
  • liver transplantation

Data availability statement

Data are available on reasonable request.

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Footnotes

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  • Contributors All authors: study conceptualisation, methodology, review of manuscript, critical revision of manuscript and approval of the final version of the manuscript. ODT: data acquisition, data analysis and interpretation, first draft of the manuscript. VTK: data acquisition. VA: study supervision and guarantor

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

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  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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