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Case report
Late-onset tacrolimus-induced colitis associated with delayed mucosal healing: a case report
  1. Scott James Mcildowie1,
  2. Antonia MD Churchhouse2,
  3. Katie Robertson3,
  4. Jonathan M Blackwell2
  1. 1 Western General Hospital, NHS Scotland, Edinburgh, UK
  2. 2 Edinburgh IBD Unit, Western General Hospital, Edinburgh, UK
  3. 3 Department of Pathology, Western General Hospital, Edinburgh, UK
  1. Correspondence to Dr Jonathan M Blackwell, Western General Hospital, Edinburgh, UK; jonathan.blackwell{at}


Tacrolimus is a calcineurin inhibitor rarely associated with gastrointestinal injury and reported only a handful of times in the literature. We present a case report demonstrating late-onset colitis in a patient taking tacrolimus for years, with typical histological features, associated with delayed mucosal healing. We hope this highlights the potential variability in both presentation and resolution in cases of tacrolimus-induced colitis.


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  • Contributors The authors confirm the contribution to the case report as follows: Preparing the draft manuscript: SJM and AMDC. Reviewing and preparing the final version of the manuscript: SJM, AMDC, KR and JMB.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.