PT  - JOURNAL ARTICLE
AU  - van der Sluis, WB
AU  - Bouman, M
AU  - Meijerink, WJHJ
AU  - Neefjes-Borst, EA
AU  - van Bodegraven, AA
TI  - Refractory diversion neovaginitis in a sigmoid-colon-derived neovagina: clinical and histopathological considerations
AID  - 10.1136/flgastro-2015-100602
DP  - 2016 Jul 01
TA  - Frontline Gastroenterology
PG  - 227--230
VI  - 7
IP  - 3
4099  - http://fg.bmj.com/content/7/3/227.short
4100  - http://fg.bmj.com/content/7/3/227.full
SO  - Frontline Gastroenterol2016 Jul 01; 7
AB  - Colonic segments are being used as pedicled grafts in neovaginoplasty, a surgical procedure to (re)construct a (neo)vagina. A disadvantage of using colonic grafts is the potential occurrence of neovaginal complications due to diversion from the faecal stream. Here, we report a case of severe, refractory diversion colitis of the sigmoid neovagina, so-called ‘diversion neovaginitis’, in a 42-year-old woman with complete androgen insensitivity syndrome. Neovaginal biopsy specimens showed colonic-type mucosa with strong increase of lymphoplasmacellular infiltrate in the lamina propria, ulceration with fibrinoid deposition and some crypt irregularity. Endoscopy showed erythematous mucosa, superficial ulceration, mucus discharge and multiple pseudopolyp-like lesions. Local application of mesalazine foam enemas and sodium butyrate enemas initially gave symptom relief. However, this was a temporary effect, ultimately necessitating removal of the neovaginal construct. It is important that all patients are informed about neovaginal bowel complications, for example, diversion neovaginitis. Regular medical and endoscopic follow-up appears recommendable.