RT Journal Article SR Electronic T1 A practical guide to thiopurine prescribing and monitoring in IBD JF Frontline Gastroenterology JO Frontline Gastroenterol FD BMJ Publishing Group Ltd SP flgastro-2016-100738 DO 10.1136/flgastro-2016-100738 A1 Ben Warner A1 Emma Johnston A1 Monica Arenas-Hernandez A1 Anthony Marinaki A1 Peter Irving A1 Jeremy Sanderson YR 2016 UL http://fg.bmj.com/content/early/2016/08/29/flgastro-2016-100738.abstract AB Thiopurines are often the mainstay of treatment for many patients with inflammatory bowel disease. As such, a general understanding of the evidence behind their use and of their metabolism is extremely useful in clinical practice. This review gives a practical overview of thiopurine metabolism, the importance of thiopurine S-methyltransferase testing prior to the start of therapy and the monitoring of thioguanine nucleotide levels while on treatment, guiding a personalised approach to optimising thiopurine therapy.