RT Journal Article SR Electronic T1 How to manage adult coeliac disease: perspective from the NHS England Rare Diseases Collaborative Network for Non-Responsive and Refractory Coeliac Disease JF Frontline Gastroenterology JO Frontline Gastroenterol FD BMJ Publishing Group Ltd SP flgastro-2019-101191 DO 10.1136/flgastro-2019-101191 A1 Elisabeth Megan Rose Baggus A1 Marios Hadjivassiliou A1 Simon Cross A1 Hugo Penny A1 Heidi Urwin A1 Sarah Watson A1 Jeremy Mark Woodward A1 David S Sanders YR 2019 UL http://fg.bmj.com/content/early/2019/08/07/flgastro-2019-101191.abstract AB Adult coeliac disease (CD) affects approximately 1% of the population. Most patients diagnosed will respond to a gluten-free diet; however, up to 30% may have persisting symptoms. Such patients may have ongoing issues associated with adherence, non-responsive CD or refractory CD. This article provides a clinical overview of how to manage this group of patients with persisting symptoms, including an investigational algorithm and details of how to contact the National Health Service England Rare Diseases Collaborative Network for Non-Responsive and Refractory Coeliac Disease. We hope this will be a valuable source of contemporary information for all UK gastroenterologists and internationally.