TY - JOUR T1 - Putting TDM knowledge into practice JF - Frontline Gastroenterology JO - Frontline Gastroenterol SP - 327 LP - 327 DO - 10.1136/flgastro-2018-101159 VL - 10 IS - 4 AU - Alan C Moss Y1 - 2019/10/01 UR - http://fg.bmj.com/content/10/4/327.abstract N2 - ‘Knowledge is of no value unless you put it into practice’ is a quote usually attributed to Anton Chekov. It is advice particularly relevant to therapeutic drug monitoring (TDM) of infliximab (IFX) in patients with inflammatory bowel disease (IBD). Several observational studies have identified low IFX trough levels, or antibodies to IFX, or both, as a factor in the loss of response to this drug in patients with IBD.1 In addition, intervention studies to prospectively adjust IFX dosing to maintain a range of trough levels have shown some impact on long-term outcomes (IBD).2 Collectively, these data implied that using TDM routinely in the clinic could improve outcomes, and minimise risk of adverse events, for patients. Whether this assumption is correct can only be answered with longitudinal studies from the ‘real world’. Recent guidelines have recommended … ER -