PT  - JOURNAL ARTICLE
AU  - Oliver D Tavabie
AU  - William Bernal
TI  - How to manage: acute liver failure
AID  - 10.1136/flgastro-2018-101105
DP  - 2020 Jan 01
TA  - Frontline Gastroenterology
PG  - 70--74
VI  - 11
IP  - 1
4099  - http://fg.bmj.com/content/11/1/70.short
4100  - http://fg.bmj.com/content/11/1/70.full
SO  - Frontline Gastroenterol2020 Jan 01; 11
AB  - Acute liver failure (ALF) is a rare but life-threatening clinical syndrome with a broad range of causes. Significant improvements in outcome have occurred over the last 50 years, resulting not only from incremental improvements in specialist critical care and a step-change following the introduction of transplantation for this indication, but also better and more effective treatment started early at the site of first presentation.1 2 Emergency liver transplantation (LTx) remains an important intervention and the decision regarding the need for LTx remains key to management, though non-transplant therapies now appear effective for many causes of the condition. In this short review, we will outline issues in the recognition and management of ALF and ongoing challenges in its treatment.