TY - JOUR T1 - How achievable are STRIDE-II treatment targets in real-world practice and do they predict long-term treatment outcomes? JF - Frontline Gastroenterology JO - Frontline Gastroenterol DO - 10.1136/flgastro-2022-102309 SP - flgastro-2022-102309 AU - Susanna Meade AU - Emma Routledge AU - Esha Sharma AU - Sailish Honap AU - Sebastian Zeki AU - Shuvra Ray AU - Simon H C Anderson AU - Jeremy Sanderson AU - Joel Mawdsley AU - Peter M Irving AU - Mark A Samaan Y1 - 2022/12/07 UR - http://fg.bmj.com/content/early/2022/12/06/flgastro-2022-102309.abstract N2 - Objective The second iteration of the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE-II) initiative recommends use of the Simple Endoscopic Score for Crohn’s disease (SES-CD) as a treatment target for patients with CD. We aimed to assess whether the STRIDE-II endoscopic endpoints are achievable and whether the degree of mucosal healing (MH) affects long-term outcomes.Design/method We performed a retrospective observational study between 2015 and 2022. Patients with CD who had baseline and follow-up SES-CD scores after biological therapy initiation were included. The primary outcome was treatment failure, defined as the need for: (1) change of biological therapy for active disease (2) corticosteroid use (3) CD-related hospitalisation or (4) surgery. We compared rates of treatment failure with the degree of MH achieved. Patients were followed up until treatment failure or study end (August 2022).Results 50 patients were included and followed up for median 39.9 (34.6–48.6) months. Baseline characteristics: 62% male, median age 36.4 (27.8–43.9) years, disease distribution (L1: 4, L2: 11, L3: 35, perianal: 18). The proportion of patients achieving STRIDE-II end-points were: SES-CD≤2–25 (50%) and >50% reduction in SES-CD—35 (70%). Failure to achieve SES-CD≤2 (HR 11.62; 95% CI 3.33 to 40.56, p=0.003) or >50% improvement in SES-CD (HR 30.30; 95% CI 6.93 to 132.40, p<0.0001) predicted treatment failure.Conclusion Use of SES-CD is feasible in real-world clinical practice. Achieving an SES-CD≤2 or a greater than 50% reduction, as set out by STRIDE-II, is associated with reduced rates of overall treatment failure including CD-related surgery.Data are available upon reasonable request. Data will be shared upon reasonable request to the authors. ER -