Statistical analysis of enzymes compared with placebo for reduction of irritable bowel syndrome-diarrhoea symptoms in enzyme subgroup
| Symptom (0–10 severe) | Mean with placebo | Mean with PEZ as No 1 drug | p Value (PEZ as No 1 drug) | Mean with PEZ as choice | p Value (PEZ as choice) |
|---|---|---|---|---|---|
| Cramping | 3.50±2.73 | 1.42±1.88 | 0.006 | 1.09±1.69 | 0.001 |
| Bloating | 2.72±1.90 | 1.31±1.56 | 0.009 | 0.90±1.30 | 0.000 |
| Borborygami | 3.25±2.07 | 1.90±1.95 | 0.006 | 1.37±1.62 | 0.001 |
| Nausea | 0.53±0.92 | 0.26±0.53 | 0.057 | 0.21±0.53 | 0.034 |
| Urgency | 4.63±2.67 | 2.14±2.00 | 0.002 | 1.79±1.93 | 0.000 |
| No of stools | 1.89±1.03 | 0.79±0.91 | 0.000 | 0.68±0.88 | 0.000 |
| Duration attack (min) | 98.94±92.76 | 88.54±181.81 | 0.898 | 53.47±86.45 | 0.072 |
| Sweating | 0.72±1.18 | 0.34±0.63 | 0.181 | 0.28±0.60 | 0.106 |
| Stool consistency | 12.00±7.12 | 4.19±5.24 | 0.000 | 3.55±5.50 | 0.000 |
| Abdominal pain | 3.64±2.70 | 1.45±1.83 | 0.003 | 1.14±1.88 | 0.000 |
PEZ, pancrealipase.