Investigations	Potential results	Clinical management plan: abnormal results
Dietary assessment	Inadequate dietary intake	Dietary advice and consider oral nutritional supplements. Refer for specialist dietetic assessment and advice.
Symptom assessment	No other GI symptoms present	Discuss with supervising clinician or Request OGD, colonoscopy, CT chest, abdomen and pelvis.
Symptom assessment	If GI symptoms present	Follow algorithm.
Routine and additional blood screen (pages 2–3) and myeloma screen	Abnormal results, eg, thyrotoxicosis, new onset diabetes mellitus, Addison's disease	Follow treatment of abnormal results (pages 2–3).
OGD Colonoscopy CT chest abdomen and pelvis	Organic cause (eg, infection, inflammation, neoplastic)	Discuss with supervising clinician within 24 h.
OGD Colonoscopy CT chest abdomen and pelvis	No organic cause identified	Refer to dietitian and review regularly. Consider psychological causes, eg, depression/eating disorder. Refer to appropriate cancer MDT for consideration of PET scan.

GI, gastrointestinal; OGD, oesophago-gastroduodenoscopy; PET, position emission tomography.