Detecting inflammation: a comparison of CRP and FCP against histology, the reference ‘gold standard’
| Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | |
|---|---|---|---|---|
| CRP cut-off | ||||
| 10 | 44 | 87 | 38 | 89 |
| 20 | 28 | 95 | 50 | 88 |
| 30 | 22 | 97 | 57 | 87 |
| FCP cut-off (µg/g) | ||||
| 8 | 100 | 51 | 30 | 100 |
| 25 | 95 | 53 | 30 | 98 |
| 50 | 90 | 60 | 33 | 97 |
| 75 | 71 | 74 | 37 | 92 |
| 100 | 68 | 82 | 44 | 92 |
| 150 | 61 | 86 | 52 | 91 |
CRP (normal range: 0–10 mg/L). CRP data available in 114 (of the 119 patients).
CRP, C-reactive protein; FCP, faecal calprotectin; NPV, negative predictive value; PPV, positive predictive value.