Drugs used in the treatment of cyclic vomiting syndrome, and their suggested dosages
| Setting | Drug | Suggested dosage |
|---|---|---|
| Terminating the acute episode | ▸ Sumatriptan | ▸ Intranasally: 20 mg as a single dose, maximum dose of 40 mg per day. Subcutaneous: 6 mg as a single dose, maximum dose of 12 mg per day. |
| ▸ Lorazepam | ▸ 0.5–2 mg up to four times daily. | |
| ▸ Ondansetron | ▸ 8 mg three times daily. | |
| Prolonging the interepisodic phase with prophylactic therapy | ▸ Tricyclic antidepressants (eg, amitriptyline) | ▸ 10–150 mg per day. |
| ▸ Zonisamide | ▸ 100–700 mg per day. | |
| ▸ Levetiracetam | ▸ 500 mg–3 g per day. | |
| ▸ Coenzyme Q10 | ▸ 300–500 mg per day. | |
| ▸ L-carnitine | ▸ 990 mg three times daily. | |
| ▸ Propranolol | ▸ 80 mg per day. | |
| ▸ Erythromycin | ▸ 250 mg three times daily. | |
| ▸ Cyproheptadine | ▸ 4–8 mg three times daily. | |
| ▸ Aprepitant | ▸ 40–125 mg per day twice weekly. |