Table 1

Clinical data for all patients who had abnormal liver function tests I

Patient IDAgeSexCancerRegimenPathologyPeak ALTTreatmentOther autoimmune effects
I1(_08)72MMelanomaPem then Ipi (H)Hepatitis706PrednisoloneColitis
I+N1(_38)67MMelanomaIpi and Niv together (H)Hepatitis73Methylprednisolone, prednisolone, infliximabColitis, rash, hypoadrenalism
I2, P1(_07)76FMelanomaIpi (H), then Pem (H)Hepatitis122(I), 699(P)Prednisolone, MMF, tacrolimusColitis
I+N2(_72)63MMelanomaIpi and Niv together(H)Hepatitis88PrednisoloneColitis, rash
I+N3(_40)70MMelanomaIpi and Niv together (H)Hepatitis434PrednisoloneColitis
I3(_87)42MMelanomaPem then Ipi (H)Hepatitis1932Dexamethasone, prednisolone, MMF
I+N4(_59)43FMelanomaIpi and Niv together (H)Hepatitis152PrednisoloneRash
I+N5(_83)46MMelanomaIpi and Niv together (H)Hepatitis834Prednisolone, MMF
I4(_038)65FMelanomaIpi only (H)Hepatitis1635Prednisolone
N1(_42)71MRenal CellNiv only (H)Hepatitis102No treatment
P2(_91)61MMelanomaPem only (H)Hepatitis824Methylprednisolone, prednisolone
I+N6(_17)49FMelanomaIpi and Niv together (H)Hepatitis2854Methylprednisolone, prednisolone, MMF, infliximab
I+N7(_002)45FMelanomaIpi and Niv together (H)Hepatitis610Prednisolone, MMFRash, hypoadrenalism, hypothyroidism, Type 1 diabetes, mucositis
I+N8(_44)51MMelanomaIpi and Niv together (H)Hepatitis790Methylprednisolone, prednisolone, MMF
I+N9(_834)21FMelanomaIpi and Niv together (H)Hepatitis422Methylprednisolone, prednisolone, MMFGastritis, pancreatitis
P3(_92)73MEpithelial mesotheliomaPem only (H)Hepatitis1377Methylprednisolone, prednisolone
CHKMT238(_97)71FMelanomaBlinded Niv/Ipi (H)Hepatitis299Prednisolone, MMF
I+N10(_58)37FMelanomaIpi and Niv together (H)Hepatitis214PrednisoloneRash, hyperthyroidism
P4(_272)75FNon-small cell lungPem only (C)Cholangitis444Prednisolone, ursodeoxycholic acid
P6(_896)69MNon-small cell lungPem only (H)Hepatitis132No treatmentPruritus, thyrotoxicosis
I+N16(_077)29MMelanomaIpi and Niv together (H)Hepatitis1343Methylprednisolone, prednisolone
  • (H) indicates which agent patient was on when they developed hepatitis. (C) indicates patient developed cholangiopathy. Patient IDs are indicative of which regimen patients were on when they developed colitis.

  • Ipi, ipilimumab (anti-CTLA-4); MMF, mycophenolate mofetil; Niv, nivolumab (anti-PD-1 antibody); P, Pem, pembrolizumab (anti-PD-1 antibody).