Prognostic scores in alcoholic hepatitis
| Score | Variables | Calculation | Interpretation | |||
| mDF | Prothrombin time (PT), control PT and bilirubin | (4.6×(patient’s PT−control PT))+bilirubin (mg/dL) or (bilirubin (µmol/L)/17) | Severe disease: ≥32 | |||
| GAHS | Age, WCC, urea, PT ratio/INR, bilirubin | 1 | 2 | 3 | Severe disease: ≥9 | |
| Age | <50 | ≥50 | ||||
| WCC (109/L) | <15 | ≥15 | ||||
| Urea (mmol/L) | <5 | ≥5 | ||||
| PTr/INR | <1.5 | 1.5–2.0 | >2.0 | |||
| Bilirubin (umol/L) | <125 | 125–250 | >250 | |||
| MELD | Bilirubin, creatinine and INR | 3.78×ln(serum bilirubin (mg/dL))+11.2×ln(INR)+9.57×ln(serum creatinine (mg/dL))+6.43 | No clear optimal cut-off for severe disease; proposed values range from 18 to 30.5 but ≥21 is gaining acceptancy | |||
| ABIC | Bilirubin, creatinine, age and INR | (Age, years×0.1)+(serum bilirubin, md/dL×0.08)+(INR×0.8)+(serum creatinine, mg/dL×0.3) | <6.71: low risk 6.71–9.0: intermediate risk >9.0: high risk | |||
| Lille | Age albumin day 0, INR day 0, creatinine day 0, bilirubin days 0 and 7 | R=3.19−(0.101×age in years)+(0.147×albumin day 0 in g/L)+(0.0165×ECBL in μM)−(0.206×renal insufficiency)*−(0.0065×bilirubin day 0 in μM)−(0.0096×INR) Score=EXP(−R)/(1+EXP(−R)) | Response: <0.45 Non-response: ≥0.45 | |||
*Renal Insufficiency: Creatinine >115 µM=1; Creatinine<115 uM=0
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ABIC, Age, Bilirubin, INR and Creatinine; ECBL, early change in bilirubin; GAHS, Glasgow Alcoholic Hepatitis score; INR, International Normalised Ratio; MELD, model for end-stage liver disease; PTr, prothrombin time ratio; WCC, white cell count; mDF, modified Maddrey’s discriminant function.