Clinical criteria | |
Alcohol | Excessive alcohol consumption for ≥6 months Men: >4 drinks (approx. 50–60 g alcohol)/day Women: >3 drinks (approx. 40 g alcohol)/day |
Abstinence | <60 days before onset of jaundice |
Jaundice | <8 weeks duration |
Laboratory criteria | |
Bilirubin | >3 mg/dL (50 µmol/L)* |
AST IU/L | >50 |
AST:ALT ratio | >1.5 |
AST and ALT (IU/L) | Both <400 |
Other causes of liver disease excluded | Viral hepatitis, biliary obstruction, autoimmune liver disease and Wilson disease |
*See text for authors’ comment.
ALT, alanine aminotransferase; AST, aspartate aminotransferase.