Table 1

Sensitivity and specificity of FC≥100 µg/g faeces compared with FIT≥10 µg Hb/g faeces for organic enteric disease in those with change of bowel habit using McDonald et al, Godber et al and Mowat et al as the comparators

OEDDisease prevalence (%)Sensitivity % CI)P valueSpecificity % (CI)P valueNPV % (CI)PPV % (CI)
FIT≥10µ/g comparator: McDonald et al*30.757.0 (45.8 to 67.6)99.0 (96.3 to 99.9)83.8 (78.5 to 88.0)96.1 (85.4 to 99.4)
FIT≥10 µg/g comparator: Godber et al*9.371.1 (55.5 to 83.2)79.5 (75.4 to 83.1)96.4 (94.0 to 97.9)26.2 (18.9 to 35.1)
FIT≥10 µg/g comparator: Mowat et al*13.668.6 (58.7 to 77.5)83.6 (80.6 to 86.4)94.4 (92.2 to 96.0)39.8 (32.6 to 47.4)
FC≥100 µg/g
 50–59 years5.865.0 (41.0 to 84.0)1.085.0 (80.6 to 88.6)0.1197.5 (94.8 to 98.9)21.0 (12.1 to 33.5)
 40–49 years5.588.9 (63.9 to 98.1)0.8189.4 (85.3 to 92.5)0.00199.3 (97.2 to 99.9)32.7 (20.4 to 47.7)
 30–39 years3.6100 (62.9 to 100)0.05191.7 (87.2 to 94.7)<0.001100 (97.9 to 100)31.0 (16.0 to 51.0)
 18–29 years8.7100 (83.4 to 100)<0.00189.3 (84.7 to 92.6)0.002100 (98.0 to 100)47.2 (33.5 to 61.2)
  • FC, faecal calprotectin; FIT, faecal immunochemical test for haemoglobin; NPV, negative predictive value; OED, organic enteric disease, a composite of colorectal cancer, significant adenomatous polyps and inflammatory bowel disease; PPV, positive predictive value.