Risk groups | ||||
High | Moderate | Low | Total | |
Age (years) median (IQR) | 41 (28) | 34.5 (17.3) | 32 (23) | |
Gender | ||||
Female | 28 (26%) | 67 (62%) | 13 (12%) | 108 (47.3%) |
Male | 49 (41%) | 61 (51%) | 10 (8%) | 120 (52.6%) |
Ethnicity | ||||
Caucasian | 48 (33%) | 84 (58%) | 12 (8%) | 144 (63.2%) |
South Asian | 26 (38%) | 34 (50%) | 8 (12%) | 68 (29.8%) |
Black | 3 (19%) | 10 (63%) | 3 (19%) | 16 (7%) |
IBD phenotype | ||||
CD | 52 (34%) | 88 (57%) | 14 (9%) | 154 (67.5%) |
UC | 25 (34%) | 40 (54%) | 9 (12%) | 74 (32.5%) |
Current medical therapy | ||||
Mesalazine | 15 (28%) | 17 (32%) | 21 (40%) | 53 (23.2%) |
Thiopurine | 31 (33%) | 63 (67%) | 0 (0%) | 94 (41.2%) |
Methotrexate | 2 (100%) | 0 (0%) | 0 (0%) | 2 (0.9%) |
Tofacitinib | 1 (33%) | 2 (67%) | 0 (0%) | 3 (1.3%) |
Infliximab | 26 (37%) | 45 (63%) | 0 (0%) | 71 (31.1%) |
Adalimumab | 12 (31%) | 27 (69%) | 0 (0%) | 39 (17.1%) |
Vedolizumab | 4 (27%) | 11 (73%) | 0 (0%) | 15 (6.6%) |
Ustekinumab | 13 (48%) | 14 (52%) | 0 (0%) | 27 (11.8%) |
Combination therapy(biologic +immunomodulator) | 18 (35%) | 34 (65%) | 0 (0%) | 52 (22.8%) |
There were no significant differences in ethnicity, age, gender or IBD phenotype between risk groups. Overall immunosuppression use was significantly greater in the moderate-risk group (p<0.001) compared with the high-risk group.
CD, Crohn's disease; IBD, inflammatory bowel disease; UC, ulcerative colitis.