Table 2

Prevalence of histopathological features in patients with AIH and with other liver diseases

AuthorNumber% Interface hepatitis (n)% Plasma cell prominence% Rosettes% Emperipolesis% Portal tract/bile duct lesionsOther features
AIHCAIHCAIHCAIHCAIHCAIHC AIH
Suzuki et al 16 2819*1001008632754175375753
de Boer et al 17 6362†87634827492378502818Steatosis 3
Granuloma 11
Balitzer et al 18 8820‡
13§
8015
77
4920
8
330
38
6550
77
46100
62
Copper,
CK-199 stains
Gurung et al 19 4342†654060¶26¶371751246025Endotheliitis
Kupffer cell hyaline
Median (range) 83 (65–100) 63 (15–100) 55 (48–86) 26 (8–32) 43 (33–75) 23 (0–41) 70 (51–78) 50 (24–77) 51 (28–60) 53 (25–100)
  • *DILI (hepatocellular).

  • †Chronic viral hepatitis.

  • ‡PBC.

  • §Non-autoimune.

  • ¶Defined as plasma cell clusters.

  • AIH, autoimmune hepatitis; DILI, drug-induced liver injury; PBC, primary biliary cholangitis.