Table 1

Hypermobility disorders

Condition	Features	Diagnosis
Joint hypermobility	Either localised, peripheral or generalised. May be symptomatic or asymptomatic.	Often not pathological.
Hypermobile spectrum disorder	Generalised joint hypermobility (with allowances for age but not environmental factors). Varied connective tissue and other symptoms (unclear evidence for true association).	Clinical constellation of symptoms but not fulfilling diagnostic criteria for hEDS. Genetic basis unknown. Molecular basis unknown. Pathogenesis of associated symptoms unknown.
Hypermobile Ehlers Danlos syndrome	Generalised joint hypermobility (with allowances for age but not environmental factors). Clinical features suggestive of a connective tissue disorder. Female preponderance (unusual for a presumed autosomal dominant condition). Other associated symptoms (unclear evidence for true association).	Clinical constellation of symptoms fulfilling diagnostic criteria for hEDS, some of which may suggest an acquired connective tissue disorder and some of which suggest a heritable connective tissue disorder. Genetic basis unknown. Molecular basis unknown. Pathogenesis of associated symptoms unknown.
Other Ehlers Danlos syndrome types	Joint hypermobility, skin hyperextensibility and tissue/blood vessel fragility.	Clinical constellation of symptoms. Genetic basis known. Molecular basis known.

Joint hypermobility syndrome has now been incorporated into hypermobile spectrum disorder or hEDS.1 2
hEDS, hypermobile Ehlers-Danlos syndrome.