Disease burden and suffering at baseline and Y2
| Characteristics* | Baseline | Y2 | Mean difference (95% CI) |
| SCCAI | 3.6±3.3† (n=63) | 1.5±1.5† (n=37) | −2.2 (−3.1 to –1.3) (n=37) |
| P-SCCAI | 4.9±4.0† (n=62) | 2.6±2.6† (n=35) | −2.3 (−3.3 to –1.4) (n=35) |
| PRISM (physician) | 3.5 (2.0–6.8)‡ (n=63) | 5.5 (3.6–6.9)‡ (n=34) | 1.6 (0.8 to 2.4) (n=34) |
| PRISM (patient) | 4.7 (2.6–6.9)‡ (n=63) | 5.4 (3.2–8.0)‡ (n=33) | 0.5 (−0.3 to 1.4) (n=33) |
| SIBDQ | 47.0±13.6† (n=63) | 56.1±11.1† (n=35) | 10.3 (6.4 to 14.1) (n=35) |
| PHQ-9 | 7.2±6.6† (n=63) | 4.9±5.5† (n=35) | −3.4 (−4.9 to –1.9) (n=35) |
| RFIPC | 2.9±2.3† (n=63) | 2.2±2.0† (n=35) | −1.0 (−1.5 to –0.4) (n=35) |
| WPAI-GH | |||
| Total activity impairment (%) | 40.0 (0.0–70.0)‡ (n=60) | 5.0 (0.0–30.0)‡ (n=34) | −19.1 (-31.5,–6.7) (n=34) |
| Total work productivity impairment (%) | 30.0 (10.0–60.0)‡ (n=38) | 0.0 (0.0–30.0)‡ (n=23) | −25.3 (−43.1 to –7.5) (n=19) |
| Absenteeism (%) | 0.0 (0.0–0.0)‡ (n=38) | 0.0 (0.0–0.0)‡ (n=23) | −13.4 (−29.1 to 2.3) (n=19) |
| Presenteeism (%) | 30.0 (10.0–55.0)‡ (n=40) | 0.0 (0.0–30.0)‡ (n=23) | −25.2 (−41.6 to –8.9) (n=21) |
*Higher scores for SCCAI/P-SSCAI, PHQ-9, RFIPC and WPAI and lower scores for PRISM and SIBDQ indicate greater burden.
†Mean±SD.
‡Median (IQR).
PHQ-9, Patient Health Questionnaire; PRISM, Pictorial Representation of Illness and Self Measure; P-SCCAI, Patient mModified Simple Clinical Colitis Activity Index; RFIPC, Rating Form of IBD Patient Concerns; SCCAI, Simple Clinical Colitis Activity Index; SIBDQ, Short Inflammatory Bowel Disease Questionnaire; WPAI-GH, Work Productivity and Activity Impairment General Health; Y2, year 2.